Political Effects of WWI Research Paper Example | Topics and Well Written Essays - 750 words

Political Effects of WWI - Research Paper Example They were Germany and Austria-Hungary (in 1918), Ottoman Empire (in 1922) and Russia (in 1917) (Mintz). Germany was recognized by Allied Powers as a country which launched WW1 and thus, was deprived of its overseas territories, and territories were retroceded to France in order to remain a unified German country (Effect of World War). Austria-Hungary, where the WW1 had nominally started from, was forced to cede Hungary and Balkan territories which later, proclaimed independent countries of Slovenia, Croatia, Bosnia and Czechoslovakia. Ex-empire was â€Å"trimmed down to primarily cover areas dominated by Austrian-German populations† while giving up territorial parts for Poland, Romania and Yugoslavia (Effect of World War). The Ottoman Empire, which before WW1 put together the most of Middle East lands and Turkey, was falling down due to the loss in WW1, but also to inner revolts. After the war Turkey was occupied by Allied forces, Palestine and Mesopotamia were annexed by Britain and France (Effect of World War). Later, â€Å"colonial revolts in the Middle East and in Southeast Asia† caused formation of modern independent Arab states on ex-Ottoman territories (Mintz). Russian Empire was the only winner country among ceased empires, and the reason of its fall was Russian Civil War of 1917. In this way, by the end of WW1 Russian monarchy was overthrown (Effect of World War). Bolsheviks came to power and Baltic territories - Estonia, Latvia and Lithuania, - managed to proclaim independence. Along with Germany, Russia gave up a part of Empire for Poland. All other territories later constructed the USSR, headed by Vladimir Lenin (Myson). A new Russian political regime, Bolshevism and later, Communism, was established as a part of a general trend. Citizen of the countries, especially of ones which experienced the greatest losses in WW1, were disappointed in their governments, and thus, new regimes started to increase

Oncogenes and Breast Cancer Term Paper Example | Topics and Well Written Essays - 1500 words

Oncogenes and Breast Cancer - Term Paper Example Thus, classification of tumors in diverse types and subtypes along with the identification of individuals who are at the potential risk of cancer is gaining prevalence. A combination of data procured from gene-expression and genomic information aids in the detection of possible new targets for designing high-throughput screening strategies for designing drugs that will lead to advances in cancer cell-targeted therapy. The present article deals with the importance of understanding for oncogenes to comprehend breast cancer. Introduction Cancer is known as malignant neoplasm, the hallmark characteristic involves uncontrolled proliferation of cells. Under normal conditions cells grow, divide and die, but in a genetic defect called mutation occur in cancer cells leading to the formation of an abnormal DNA. As genes are the basic control machine of the cells, alteration of any kind may bring devastating consequences, or malignancy. When compared with the normal cells, where damage of any k ind is taken care by the repair system, tumor cells do not have any repair mechanism for the damaged DNA and there is a constant proliferation of cells without displaying senescence hence, generating a series of abnormal cells, with altered cellular pathways for uncontrolled proliferation, figuring malignant tumors (Alberts 2007; Katzang et al. 2009). (Normal cell cycle) (Genetic mutation- causes alteration in genes) (Alberts 2007) Cancer cells manifest, to varying degrees, four characteristics that distinguish them from normal cells, comprising- uncontrolled proliferation, de-differentiation and loss of function, invasiveness and metastasis (Rang et al. 2007). The Genesis of a Cancer Cell A normal cell turns into a cancer cell because of one or more mutations in its DNA, which can be inherited or acquired. In case of the breast cancer, woman who inherits a single defective copy of either of these tumor suppressor genes BRCA1 and BRCA2 displays an augmented risk of developing breast cancer. However, carcinogenesis is a complex, multistage process, usually involving more than one genetic change. Other epigenetic factors responsible for carcinogenesis involve epigenetic factors, such as level of hormones in the body, exposure to carcinogens and tumor promoting agents. These epigenetic factors do not produce cancer by themselves but enhances the likelihood of genetic mutation(s) resulting in cancer. These genetic changes are categorized as - A. The activation of proto-oncogenes to oncogenes: Proto-oncogenes are the normal genes present in the cells and are responsible for controlling cell division, cell differentiation and apoptosis. A triggering factor such as a virus or exposure to any carcinogen brings malignant changes in the cell. B. The inactivation of tumor suppressor genes: A cell has the mechanism to protect itself from uncontrolled proliferation and tumor formation due to expression of genes called tumor suppressor genes. These genes possess the ability to suppress malignant changes and are also referred as antioncogenes. Mutation in proto-oncogenes or tumor suppressor genes results in the proliferation of tumor. Thus, a loss of function of tumor supp